“Spanish fly” does have a direct physical effect.
Spanish fly is made from the meloid or “blister” beetle, a species that contains a small amount of the chemical cantharidin. Humans have a natural allergic reaction to cantharidin, which manifests as irritation of the urinary tract. In men, the irritation can be mistaken for arousal because it causes an erection. But the erection may not subside, leading instead to a dangerous condition (priapism) that can cause clotting in or gangrene of the penis.
Cantharidin is obtained by drying and crushing a meloid beetle into powder. Or, you could dine on a creature that eats meloid beetles, such as certain frogs—which explains why frog legs are a reputed aphrodisiac.
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